Long‐term effect of unilateral pallidotomy on levodopa‐induced dyskinesia
Identifieur interne : 001C03 ( Main/Exploration ); précédent : 001C02; suivant : 001C04Long‐term effect of unilateral pallidotomy on levodopa‐induced dyskinesia
Auteurs : Galit Kleiner-Fisman [Canada] ; Andres Lozano [Canada] ; Elena Moro [Canada] ; Yu-Yan Poon [Canada] ; Anthony E. Lang [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-07-30.
English descriptors
- KwdEn :
- Antiparkinson Agents (adverse effects), Child, Child, Preschool, Deep Brain Stimulation (methods), Dyskinesia, Drug-Induced (surgery), Female, Functional Laterality (physiology), Humans, Levodopa (adverse effects), Longitudinal Studies, Male, Pallidotomy (methods), Parkinson Disease (drug therapy), Parkinson Disease (surgery), Parkinson's disease, Severity of Illness Index, Statistics, Nonparametric, dyskinesia, pallidotomy.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- drug therapy : Parkinson Disease.
- methods : Deep Brain Stimulation, Pallidotomy.
- physiology : Functional Laterality.
- surgery : Dyskinesia, Drug-Induced, Parkinson Disease.
- Child, Child, Preschool, Female, Humans, Longitudinal Studies, Male, Severity of Illness Index, Statistics, Nonparametric.
Abstract
Unilateral pallidotomy has been effectively used to treat parkinsonism and reduce levodopa induced dyskinesia (LID). We sought to determine the long‐term effects of pallidotomy on LID in 10 patients who had initial benefit from pallidotomy but went on to require DBS surgery for symptom progression. The Dyskinesia Rating Scale (DRS) was used to rate and quantify LID in a blinded fashion. Though sample size was small, there was a trend towards a reduction in LID lasting up to 12 years suggesting that posteroventral pallidotomy may provide sustained benefit in reducing LID. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23155
Affiliations:
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We sought to determine the long‐term effects of pallidotomy on LID in 10 patients who had initial benefit from pallidotomy but went on to require DBS surgery for symptom progression. The Dyskinesia Rating Scale (DRS) was used to rate and quantify LID in a blinded fashion. Though sample size was small, there was a trend towards a reduction in LID lasting up to 12 years suggesting that posteroventral pallidotomy may provide sustained benefit in reducing LID. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Kleiner Isman, Galit" sort="Kleiner Isman, Galit" uniqKey="Kleiner Isman G" first="Galit" last="Kleiner-Fisman">Galit Kleiner-Fisman</name></region><name sortKey="Kleiner Isman, Galit" sort="Kleiner Isman, Galit" uniqKey="Kleiner Isman G" first="Galit" last="Kleiner-Fisman">Galit Kleiner-Fisman</name><name sortKey="Kleiner Isman, Galit" sort="Kleiner Isman, Galit" uniqKey="Kleiner Isman G" first="Galit" last="Kleiner-Fisman">Galit Kleiner-Fisman</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name><name sortKey="Lozano, Andres" sort="Lozano, Andres" uniqKey="Lozano A" first="Andres" last="Lozano">Andres Lozano</name><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><name sortKey="Poon, Yu An" sort="Poon, Yu An" uniqKey="Poon Y" first="Yu-Yan" last="Poon">Yu-Yan Poon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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